Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics.

ABSTRACT:

Background

The recent availability of genome sequences of multiple related Caenorhabditis species has made it possible to identify, using comparative genomics, similarly transcribed genes in Caenorhabditis elegans and its sister species. Taking this approach, we have identified numerous novel ciliary genes in C. elegans, some of which may be orthologs of unidentified human ciliopathy genes.

Results

By screening for genes possessing canonical X-box sequences in promoters of three Caenorhabditis species, namely C. elegans, C. briggsae and C. remanei, we identified 93 genes (including known X-box regulated genes) that encode putative components of ciliated neurons in C. elegans and are subject to the same regulatory control. For many of these genes, restricted anatomical expres

SUBMITTER: Chen N 

PROVIDER: S-EPMC1794439 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature