Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients.

ABSTRACT: We examined the gene expression profiles in arthroscopic biopsies retrieved from 10 rheumatoid arthritis patients before and after anti-TNF treatment with infliximab to investigate whether such profiles can be used to predict responses to the therapy, and to study effects of the therapy on the profiles. Responses to treatment were assessed using European League Against Rheumatism response criteria. Three patients were found to be good responders, five patients to be moderate responders and two patients to be nonresponders. The TNF-alpha status of the biopsies from each of the patients before treatment was also investigated immunohistochemically, and it was detected in biopsies from four of the patients, including all three of the good responders. The gene expression data demonstrate that a

SUBMITTER: Lindberg J 

PROVIDER: S-EPMC1794525 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature