Retroviral activation of the mir-106a microRNA cistron in T lymphoma.

ABSTRACT: Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.

SUBMITTER: Lum AM 

PROVIDER: S-EPMC1794537 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature