Global analysis of mRNA stability in the archaeon Sulfolobus.

ABSTRACT:

Background

Transcript half-lives differ between organisms, and between groups of genes within the same organism. The mechanisms underlying these differences are not clear, nor are the biochemical properties that determine the stability of a transcript. To address these issues, genome-wide mRNA decay studies have been conducted in eukaryotes and bacteria. In contrast, relatively little is known about RNA stability in the third domain of life, Archaea. Here, we present a microarray-based analysis of mRNA half-lives in the hyperthermophilic crenarchaea Sulfolobus solfataricus and Sulfolobus acidocaldarius, constituting the first genome-wide study of RNA decay in archaea.

Results

The two transcriptomes displayed similar half-life distributions, with medians of about five minutes

SUBMITTER: Andersson AF 

PROVIDER: S-EPMC1794556 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature