Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs.

ABSTRACT:

Background

Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. Chromosome 13 is the chromosome with the highest number of neocentromeres. We reconstructed the mammalian evolutionary history of this chromosome and characterized two human neocentromeres at 13q21, in search of information that could improve our understanding of the relationship between evolutionarily new centromeres, inactivated centromeres, and clinical neocentromeres.

Results

Chromosome 13 evolution was studied, using FISH experiments, across several diverse superordinal phylogenetic clades spanning >100 million years of evolution. The analysis revealed exce

SUBMITTER: Cardone MF 

PROVIDER: S-EPMC1794570 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature