Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins.

ABSTRACT:

Background

Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become more tissue specific. We explored the relationship between duplication events, the time at which they took place, and both the expression breadth of the duplicated genes and the cumulative expression breadth of the gene family to which they belong.

Results

We show that only duplicates that arose through post-multicellularity duplication events show a tendency to become more specifically expressed, whereas such a tendency is not observed for duplicates that arose in a unicellular ances

SUBMITTER: Freilich S 

PROVIDER: S-EPMC1794571 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature