Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics.

ABSTRACT:

Background

Transcriptional regulation plays an important role in the control of many biological processes. Transcription factor binding sites (TFBSs) are the functional elements that determine transcriptional activity and are organized into separable cis-regulatory modules, each defining the cooperation of several transcription factors required for a specific spatio-temporal expression pattern. Consequently, the discovery of novel TFBSs in promoter sequences is an important step to improve our understanding of gene regulation.

Results

Here, we applied a detection strategy that combines features of classic motif overrepresentation approaches in co-regulated genes with general comparative footprinting principles for the identification of biologically relevant regulatory elemen

SUBMITTER: Vandepoele K 

PROVIDER: S-EPMC1794593 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature