Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome.

ABSTRACT:

Background

The recent availability of genome sequences has provided unparalleled insights into the broad-scale patterns of transposable element (TE) sequences in eukaryotic genomes. Nevertheless, the difficulties that TEs pose for genome assembly and annotation have prevented detailed, quantitative inferences about the contribution of TEs to genomes sequences.

Results

Using a high-resolution annotation of TEs in Release 4 genome sequence, we revise estimates of TE abundance in Drosophila melanogaster. We show that TEs are non-randomly distributed within regions of high and low TE abundance, and that pericentromeric regions with high TE abundance are mosaics of distinct regions of extreme and normal TE density. Comparative analysis revealed that this punctate pattern evolves

SUBMITTER: Bergman CM 

PROVIDER: S-EPMC1794594 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature