Linkage disequilibrium test implies a large effective population number for HIV in vivo.

ABSTRACT: The effective size of the HIV population in vivo, although critically important for the prediction of appearance of drug-resistant variants, is currently unknown. To address this issue, we have developed a simple virus population model, within which the relative importance of stochastic factors and purifying selection for genetic evolution differs over, at least, three broad intervals of the effective population size, with approximate boundaries given by the inverse selection coefficient and the inverse mutation rate per base per cycle. Random drift and selection dominate the smallest (stochastic) and largest (deterministic) population intervals, respectively. In the intermediate (selection-drift) interval, random drift controls weakly diverse populations, whereas strongly diverse populati

SUBMITTER: Rouzine IM 

PROVIDER: S-EPMC17956 | biostudies-literature | 1999 Sep

REPOSITORIES: biostudies-literature