Comparative analysis of genome tiling array data reveals many novel primate-specific functional RNAs in human.

ABSTRACT:

Background

Widespread transcription activities in the human genome were recently observed in high-resolution tiling array experiments, which revealed many novel transcripts that are outside of the boundaries of known protein or RNA genes. Termed as "TARs" (Transcriptionally Active Regions), these novel transcribed regions represent "dark matter" in the genome, and their origin and functionality need to be explained. Many of these transcripts are thought to code for novel proteins or non-protein-coding RNAs. We have applied an integrated bioinformatics approach to investigate the properties of these TARs, including cross-species conservation, and the ability to form stable secondary structures. The goal of this study is to identify a list of potential candidate sequences that are li

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC1796608 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature