Statistical significance of cis-regulatory modules.

ABSTRACT:

Background

It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding sites forming cis-regulatory modules. Correspondingly, there has been a push to develop algorithms for the rapid detection and assessment of cis-regulatory modules. While various algorithms for this purpose have been introduced, most are not well suited for rapid, genome scale scanning.

Results

We introduce methods designed for the detection and statistical evaluation of cis-regulatory modules, modeled as either clusters of individual binding sites or as combinations of sites with constrained organization. In order to determine the statistical significance of module sites, we first need a method to det

SUBMITTER: Schones DE 

PROVIDER: S-EPMC1796902 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature