Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis.

ABSTRACT: Various DNA alterations can be caused by exposure to environmental and endogenous carcinogens. Most of these alterations, if not repaired, can result in genetic instability, mutagenesis and cell death. DNA repair mechanisms are important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNPs) in candidate genes, among which DNA repair genes are increasingly being studied. Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes, foc

SUBMITTER: Kiyohara C 

PROVIDER: S-EPMC1796947 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature