Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms.

ABSTRACT:

Background

The mapping of quantitative trait loci in rat and mouse has been extremely successful in identifying chromosomal regions associated with human disease-related phenotypes. However, identifying the specific phenotype-causing DNA sequence variations within a quantitative trait locus has been much more difficult. The recent availability of genomic sequence from several mouse inbred strains (including C57BL/6J, 129X1/SvJ, 129S1/SvImJ, A/J, and DBA/2J) has made it possible to catalog DNA sequence differences within a quantitative trait locus derived from crosses between these strains. However, even for well-defined quantitative trait loci (<10 Mb) the identification of candidate functional DNA sequence changes remains challenging due to the high density of sequence variation b

SUBMITTER: Reuveni E 

PROVIDER: S-EPMC1797019 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature