GATA3 protein as a MUC1 transcriptional regulator in breast cancer cells.

ABSTRACT:

Introduction

Recent studies have demonstrated that members of the GATA-binding protein (GATA) family (GATA4 and GATA5) might have pivotal roles in the transcriptional upregulation of mucin genes (MUC2, MUC3 and MUC4) in gastrointestinal epithelium. The zinc-finger GATA3 transcription factor has been reported to be involved in the growth control and differentiation of breast epithelial cells. In SAGE (serial analysis of gene expression) studies we observed an intriguing significant correlation between GATA3 and MUC1 mRNA expression in breast carcinomas. We therefore designed the present study to elucidate whether MUC1 expression is regulated by GATA3 in breast cancer cells.

Methods

Promoter sequence analysis of the MUC1 gene identified six GATA cis consensus elements in the 5

SUBMITTER: Abba MC 

PROVIDER: S-EPMC1797033 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature