Integrative analysis of a cancer somatic mutome.

ABSTRACT:

Background

The consecutive acquisition of genetic alterations characterizes neoplastic processes. As a consequence of these alterations, molecular interactions are reprogrammed in the context of highly connected and regulated cellular networks. The recent identification of the collection of somatically mutated genes in breast tumors (breast cancer somatic "mutome") allows the comprehensive study of its function and organization in complex networks.

Results

We analyzed functional genomic data (loss of heterozygosity, copy number variation and gene expression in breast tumors) and protein binary interactions from public repositories to identify potential novel components of neoplastic processes, the functional relationships between them, and to examine their coordinated functi

SUBMITTER: Hernandez P 

PROVIDER: S-EPMC1797053 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature