Transcription profiling of a recently colonised pyrethroid resistant Anopheles gambiae strain from Ghana.

ABSTRACT:

Background

Mosquito resistance to the pyrethroid insecticides used to treat bednets threatens the sustainability of malaria control in sub-Saharan Africa. While the impact of target site insensitivity alleles is being widely discussed the implications of insecticide detoxification--though equally important--remains elusive. The successful development of new tools for malaria intervention and management requires a comprehensive understanding of insecticide resistance, including metabolic resistance mechanisms. Although three enzyme families (cytochrome P450s, glutathione S-transferases and carboxylesterases) have been widely associated with insecticide detoxification the role of individual enzymes is largely unknown.

Results

Here, constitutive expression patterns of genes put

SUBMITTER: Muller P 

PROVIDER: S-EPMC1797171 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature