Contribution of invariant residues to the function of Rgg family transcription regulators.

ABSTRACT: The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.

SUBMITTER: Loughman JA 

PROVIDER: S-EPMC1797381 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature