Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin.

ABSTRACT: Staphylococcus aureus infections can be difficult to treat due to both multidrug resistance and the organism's remarkable ability to persist in the host. Persistence and the evolution of resistance may be related to several complex regulatory networks, such as the SOS response, which modifies transcription in response to environmental stress. To understand how S. aureus persists during antibiotic therapy and eventually emerges resistant, we characterized its global transcriptional response to ciprofloxacin. We found that ciprofloxacin induces prophage mobilization as well as significant alterations in metabolism, most notably the up-regulation of the tricarboxylic acid cycle. In addition, we found that ciprofloxacin induces the SOS response, which we show, by comparison of a wild-type stra

SUBMITTER: Cirz RT 

PROVIDER: S-EPMC1797410 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature