Analysis of a new human parechovirus allows the definition of parechovirus types and the identification of RNA structural domains.

ABSTRACT: Human parechoviruses (HPeV), members of the Parechovirus genus of Picornaviridae, are frequent pathogens but have been comparatively poorly studied, and little is known of their diversity, evolution, and molecular biology. To increase the amount of information available, we have analyzed 7 HPeV strains isolated in California between 1973 and 1992. We found that, on the basis of VP1 sequences, these fall into two genetic groups, one of which has not been previously observed, bringing the number of known groups to five. While these correlate partly with the three known serotypes, two members of the HPeV2 serotype belong to different genetic groups. In view of the growing importance of molecular techniques in diagnosis, we suggest that genotype is an important criterion for identifying viruse

SUBMITTER: Al-Sunaidi M 

PROVIDER: S-EPMC1797470 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature