Genetic Studies of the beta-hairpin loop of Rous sarcoma virus capsid protein.

ABSTRACT: The first few residues of the Rous sarcoma virus (RSV) CA protein comprise a structurally dynamic region that forms part of a Gag-Gag interface in immature virus particles. Dissociation of this interaction during maturation allows refolding and formation of a beta-hairpin structure important for assembly of CA monomers into the mature capsid shell. A consensus binding site for the cellular Ubc9 protein was previously identified within this region, suggesting that binding of Ubc9 and subsequent small ubiquitin-like modifier protein 1 (SUMO-1) modification of CA may play a role either in regulating the assembly activity of CA in immature particles or mature cores or in controlling postentry function(s) during the establishment of infection. In the present study, mutations designed to elimina

SUBMITTER: Spidel JL 

PROVIDER: S-EPMC1797520 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature