Interaction between a 54-kilodalton mammalian cell surface protein and cowpea mosaic virus.

ABSTRACT: Cowpea mosaic virus (CPMV), a plant virus that is a member of the picornavirus superfamily, is increasingly being used for nanotechnology applications, including material science, vascular imaging, vaccine development, and targeted drug delivery. For these applications, it is critical to understand the in vivo interactions of CPMV within the mammalian system. Although the bioavailability of CPMV in the mouse has been demonstrated, the specific interactions between CPMV and mammalian cells need to be characterized further. Here we demonstrate that although the host range for replication of CPMV is confined to plants, mammalian cells nevertheless bind and internalize CPMV in significant amounts. This binding is mediated by a conserved 54-kDa protein found on the plasma membranes of both huma

SUBMITTER: Koudelka KJ 

PROVIDER: S-EPMC1797570 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature