In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis.

ABSTRACT: Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.

SUBMITTER: Larsen RA 

PROVIDER: S-EPMC1797648 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature