Two complex, adenovirus-based vaccines that together induce immune responses to all four dengue virus serotypes.

ABSTRACT: Dengue virus infections can cause hemorrhagic fever, shock, encephalitis, and even death. Worldwide, approximately 2.5 billion people live in dengue-infested regions with about 100 million new cases each year, although many of these infections are believed to be silent. There are four antigenically distinct serotypes of dengue virus; thus, immunity from one serotype will not cross-protect from infection with the other three. The difficulties that hamper vaccine development include requirements of the natural conformation of the envelope glycoprotein to induce neutralizing immune responses and the necessity of presenting antigens of all four serotypes. Currently, the only way to meet these requirements is to use a mixture of four serotypes of live attenuated dengue viruses, but safety remai

SUBMITTER: Holman DH 

PROVIDER: S-EPMC1797786 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature