Bioinformatics analysis of the early inflammatory response in a rat thermal injury model.

ABSTRACT:

Background

Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and immuno-suppression. It has been hypothesized that gene expression patterns in the liver will change with severe burns, thus reflecting the role the liver plays in the response to burn injury. Characterizing the molecular fingerprint (i.e., expression profile) of the inflammatory response resulting from burns may help elucidate the activated mechanisms and suggest new therapeutic intervention. In this paper we propose a novel integrated framework for analyzing time-series transcriptional data, with emphasis on the burn-induced respo

SUBMITTER: Yang E 

PROVIDER: S-EPMC1797813 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature