Specificity and evolvability in eukaryotic protein interaction networks.

ABSTRACT: Progress in uncovering the protein interaction networks of several species has led to questions of what underlying principles might govern their organization. Few studies have tried to determine the impact of protein interaction network evolution on the observed physiological differences between species. Using comparative genomics and structural information, we show here that eukaryotic species have rewired their interactomes at a fast rate of approximately 10(-5) interactions changed per protein pair, per million years of divergence. For Homo sapiens this corresponds to 10(3) interactions changed per million years. Additionally we find that the specificity of binding strongly determines the interaction turnover and that different biological processes show significantly different link dyna

SUBMITTER: Beltrao P 

PROVIDER: S-EPMC1797819 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature