Lead and delta-aminolevulinic acid dehydratase polymorphism: where does it lead? A meta-analysis.

ABSTRACT:

Background

Lead poisoning affects many organs in the body. Lead inhibits delta-aminolevulinic acid dehydratase (ALAD), an enzyme with two co-dominantly expressed alleles, ALAD1 and ALAD2.

Objective

Our meta-analysis studied the effects of the ALAD polymorphism on a) blood and bone lead levels and b) indicators of target organ toxicity.

Data source

We included studies reporting one or more of the following by individuals with genotypes ALAD1-1 and ALAD1-2/2-2: blood lead level (BLL), tibia or trabecular lead level, zinc protoporphyrin (ZPP), hemoglobin, serum creatinine, blood urea nitrogen (BUN), dimercaptosuccinic acid-chelatable lead, or blood pressure.

Data extraction

Sample sizes, means, and standard deviations were extracted for the genotype groups.

Dat

SUBMITTER: Scinicariello F 

PROVIDER: S-EPMC1797830 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature