TNFalpha polymorphisms and risk of psoriatic arthritis.

ABSTRACT:

Background

Tumour necrosis factor alpha (TNFalpha) is a cytokine of critical importance in psoriatic arthritis.

Objectives

(1) To examine the association between TNFalpha promoter gene polymorphisms and psoriatic arthritis in two well characterised Canadian populations with the disease; (2) to carry out a meta-analysis of all TNFalpha association studies in white psoriatic arthritis populations.

Methods

DNA samples were genotyped for five TNF variants by time of flight mass spectrometry using the Sequenom platform. All five single nucleotide polymorphisms were in the 5' flanking region of TNFalpha gene at the following positions: -1031 (T-->C), -863 (C-->A), -857 (C-->T), -308 (G-->A), and -238 (G-->A). Primary analyses were based on logistic regression. Summary estim

SUBMITTER: Rahman P 

PROVIDER: S-EPMC1798211 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature