Altered gut transcriptome in spondyloarthropathy.

ABSTRACT:

Background

Intestinal inflammation is a common feature of spondyloarthropathy (SpA) and Crohn's disease. Inflammation is manifested clinically in Crohn's disease and subclinically in SpA. However, a fraction of patients with SpA develops overt Crohn's disease.

Aims

To investigate whether subclinical gut lesions in patients with SpA are associated with transcriptome changes comparable to those seen in Crohn's disease and to examine global gene expression in non-inflamed colon biopsy specimens and screen patients for differentially expressed genes.

Methods

Macroarray analysis was used as an initial genomewide screen for selecting a comprehensive set of genes relevant to Crohn's disease and SpA. This led to the identification of 2625 expressed sequence tags that are diff

SUBMITTER: Laukens D 

PROVIDER: S-EPMC1798320 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature