A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip.

ABSTRACT:

Objective

To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare.

Methods

In this 24-week, prospective, randomised, double-blind, placebo-controlled study, patients were randomly assigned to receive continuous (n = 62) or intermittent (n = 61) treatment with celecoxib 200 mg once daily. The primary efficacy end point was the area under the curve (AUC) of the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total scores between baseline and week 24 divided by the time interval. Secondary end points included the percentage of days with intake of the flare drug, the AUC of the change in the WOMAC total scores, the mean change from baseline in the WOMAC scores, and the pat

SUBMITTER: Luyten FP 

PROVIDER: S-EPMC1798410 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature