Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations.

ABSTRACT: A previous polymorphism survey of the type 2 diabetes gene CAPN10 identified a segment showing an excess of polymorphism levels in all population samples, coinciding with localized breakdown of linkage disequilibrium (LD) in a sample of Hausa from Cameroon, but not in non-African samples. This raised the possibility that a recombination hotspot is present in all populations and we had insufficient power to detect it in the non-African data. To test this possibility, we estimated the crossover rate by sperm typing in five non-African men; these estimates were consistent with the LD decay in the non-African, but not in the Hausa data. Moreover, resequencing the orthologous region in a sample of Western chimpanzees did not show either an excess of polymorphism level or rapid LD decay, suggest

SUBMITTER: Clark VJ 

PROVIDER: S-EPMC1800598 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature