Chronic Helicobacter pylori infection does not significantly alter the microbiota of the murine stomach.

ABSTRACT: We examined the impact of Helicobacter pylori infection on the murine gastric microbiota by culture and terminal-restriction fragment length polymorphism and found that neither acute nor chronic H. pylori infection substantially affected the gastric microbial composition. Interestingly, the total H. pylori burden detected by real-time PCR was significantly higher than that revealed by viable counts, suggesting that the antigenic load sustaining H. pylori-induced gastritis could be considerably higher than previously believed.

SUBMITTER: Tan MP 

PROVIDER: S-EPMC1800740 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature