Conserved intron positions in ancient protein modules.

ABSTRACT:

Background

The timing of the origin of introns is of crucial importance for an understanding of early genome architecture. The Exon theory of genes proposed a role for introns in the formation of multi-exon proteins by exon shuffling and predicts the presence of conserved splice sites in ancient genes. In this study, large-scale analysis of potential conserved splice sites was performed using an intron-exon database (ExInt) derived from GenBank.

Results

A set of conserved intron positions was found by matching identical splice sites sequences from distantly-related eukaryotic kingdoms. Most amino acid sequences with conserved introns were homologous to consensus sequences of functional domains from conserved proteins including kinases, phosphatases, small GTPases, transporte

SUBMITTER: de Roos AD 

PROVIDER: S-EPMC1800838 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature