Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease.

ABSTRACT:

Background

Late onset Alzheimer's disease (LOAD) is a common sporadic form of the illness, affecting individuals above the age of 65 yrs. A prominent hypothesis for the aetiopathology of Alzheimer's disease is that in the presence of a beta-amyloid load, individuals expressing a pathogenic form of tau protein (MAPT) are at increased risk for developing the disease. Genetic studies in this pursuit have, however, yielded conflicting results. A recent study showed a significant haplotype association (H1c) with AD. The current study is an attempt to replicate this association in an independently ascertained cohort.

Results

In this report we present the findings of a haplotype analysis at the MAPT locus. We failed to detect evidence of association of the H1c haplotype at the MAPT

SUBMITTER: Mukherjee O 

PROVIDER: S-EPMC1800865 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature