Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data.

ABSTRACT:

Background

In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred to as heritable clustering. This approach generates a progression model of altered DNA methylation from tumor tissues diagnosed at different developmental stages. The samples act as surrogates for natural progression in breast cancer and allow the algorithm to uncover distinct epigenotypes that describe the molecular events underlying this process. Furthermore, our likelihood-based clustering algorithm has great flexibility, allowing for incomplete epigenotype or clinical phenotype data and also permitting dependencies among variables.

Results

Using this heritable clustering approach, we analyzed meth

SUBMITTER: Wang Z 

PROVIDER: S-EPMC1800873 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature