Linkage of familial dilated cardiomyopathy to chromosome 9. Heart Muscle Disease Study Group.

ABSTRACT: Idiopathic dilated cardiomyopathy is a heart muscle disease of unknown etiology, characterized by impaired myocardial contractility and ventricular dilatation. The disorder is an important cause of morbidity and mortality and represents the chief indication for heart transplantation. Familial transmission is often recognized (familial dilated cardiomyopathy, or FDC), mostly with autosomal dominant inheritance. In order to understand the molecular genetic basis of the disease, a large six-generation kindred with autosomal dominant FDC was studied for linkage analysis. A genome-wide search was undertaken after a large series of candidate genes were excluded and was then extended to two other families with autosomal dominant pattern of transmission and identical clinical features. Coinheritan

SUBMITTER: Krajinovic M 

PROVIDER: S-EPMC1801493 | biostudies-literature | 1995 Oct

REPOSITORIES: biostudies-literature