"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells.

ABSTRACT:

Background

Human stem cells are viewed as a possible source of neurons for a cell-based therapy of neurodegenerative disorders, such as Parkinson's disease. Several protocols that generate different types of neurons from human stem cells (hSCs) have been developed. Nevertheless, the cellular mechanisms that underlie the development of neurons in vitro as they are subjected to the specific differentiation protocols are often poorly understood.

Results

We have designed a focused DNA (oligonucleotide-based) large-scale microarray platform (named "NeuroStem Chip") and used it to study gene expression patterns in hSCs as they differentiate into neurons. We have selected genes that are relevant to cells (i) being stem cells, (ii) becoming neurons, and (iii) being neurons. The Neur

SUBMITTER: Anisimov SV 

PROVIDER: S-EPMC1802744 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature