Sequential loading of cohesin subunits during the first meiotic prophase of grasshoppers.

ABSTRACT: The cohesin complexes play a key role in chromosome segregation during both mitosis and meiosis. They establish sister chromatid cohesion between duplicating DNA molecules during S-phase, but they also have an important role during postreplicative double-strand break repair in mitosis, as well as during recombination between homologous chromosomes in meiosis. An additional function in meiosis is related to the sister kinetochore cohesion, so they can be pulled by microtubules to the same pole at anaphase I. Data about the dynamics of cohesin subunits during meiosis are scarce; therefore, it is of great interest to characterize how the formation of the cohesin complexes is achieved in order to understand the roles of the different subunits within them. We have investigated the spatio-tempor

SUBMITTER: Valdeolmillos AM 

PROVIDER: S-EPMC1802827 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature