Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells.

ABSTRACT:

Background

Neuroblastoma, a frequently occurring solid tumour in children, remains a therapeutic challenge as existing imaging tools are inadequate for proper and accurate diagnosis, resulting in treatment failures. Nanoparticles have recently been introduced to the field of cancer research and promise remarkable improvements in diagnostics, targeting and drug delivery. Among these nanoparticles, quantum dots (QDs) are highly appealing due to their manipulatable surfaces, yielding multifunctional QDs applicable in different biological models. The biocompatibility of these QDs, however, remains questionable.

Results

We show here that QD surface modifications with N-acetylcysteine (NAC) alter QD physical and biological properties. In human neuroblastoma (SH-SY5Y) cells, NAC mo

SUBMITTER: Choi AO 

PROVIDER: S-EPMC1802956 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature