Ontology highlight
ABSTRACT:
SUBMITTER: Koster MI
PROVIDER: S-EPMC1805532 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Koster Maranke I MI Dai Daisy D Marinari Barbara B Sano Yuji Y Costanzo Antonio A Karin Michael M Roop Dennis R DR
Proceedings of the National Academy of Sciences of the United States of America 20070220 9
Mice lacking p63, a single gene that encodes a group of transcription factors that either contain (TA) or lack (DeltaN) a transactivation domain, fail to develop stratified epithelia as well as epithelial appendages and limbs. DeltaNp63 isoforms are predominantly expressed during late embryonic and postnatal epidermal development, however, the function of these proteins remains elusive. Using an epidermal-specific inducible knockdown mouse model, we demonstrate that DeltaNp63 proteins are essent ...[more]