C-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balpha.

ABSTRACT: Genomic instability (GI) is essential for the initiation and evolution of many cancers and often precedes frank neoplastic conversion. Although GI can occur at several levels, the most conspicuous examples involve gains or losses of entire chromosomes (aneuploidy), the antecedent of which may be whole genome duplication (tetraploidy). Through largely undefined mechanisms, the c-Myc oncoprotein and its downstream target, MTMC1, promote tetraploidy and other forms of GI. In myeloid cells, c-Myc and MTMC1 also regulate a common, small subset of c-Myc target genes including GP1Balpha, which encodes a subunit of the von Willebrand's factor receptor complex that mediates platelet adhesion and aggregation. Gp1balpha also participates in megakaryocyte endomitosis, a form of controlled and precise

SUBMITTER: Li Y 

PROVIDER: S-EPMC1805544 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature