Systems-level analysis and evolution of the phototransduction network in Drosophila.

ABSTRACT: Networks of interacting genes are responsible for generating life's complexity and for mediating how organisms respond to their environment. Thus, a basic understanding of genetic variation in gene networks in natural populations is important for elucidating how changes at the genetic level map to higher levels of biological organization. Here, using the well-characterized phototransduction network in Drosophila, we analyze variation in gene expression within and between two closely related species, Drosophila melanogaster and Drosophila simulans, under different environmental conditions. Gene expression levels in the pathway are largely conserved between these two sibling species. For most genes in the network, differences in level of gene expression between species are correlated with de

SUBMITTER: Landry CR 

PROVIDER: S-EPMC1805570 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature