When should potentially false research findings be considered acceptable?

ABSTRACT: Ioannidis estimated that most published research findings are false, but he did not indicate when, if at all, potentially false research results may be considered as acceptable to society. We combined our two previously published models to calculate the probability above which research findings may become acceptable. A new model indicates that the probability above which research results should be accepted depends on the expected payback from the research (the benefits) and the inadvertent consequences (the harms). This probability may dramatically change depending on our willingness to tolerate error in accepting false research findings. Our acceptance of research findings changes as a function of what we call "acceptable regret," i.e., our tolerance of making a wrong decision in acceptin

SUBMITTER: Djulbegovic B 

PROVIDER: S-EPMC1808081 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature