Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium.

ABSTRACT:

Background

The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery.

Methods and results

We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (n = 10) than in normal subjects (n = 14, P < 0.006). Left ventricular mass and CK metabolite levels in LVH were not different from those in patients with LVH and heart failure (LVH+CHF, n = 10); however, the myocardial CK pseudo firs

SUBMITTER: Smith CS 

PROVIDER: S-EPMC1808438 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature