A mathematical model for the adenylosuccinate synthetase reaction involved in purine biosynthesis.

ABSTRACT:

Background

Development of the mathematical models that adequately describe biochemical reactions and molecular-genetic mechanisms is one of the most important tasks in modern bioinformatics. Because the enzyme adenylosuccinate synthetase (AdSS) has long been extensively studied, a wealth of kinetic data has been accumulated.

Results

We describe a mathematical model for the reaction catalyzed by AdSS. The model's parameters were fitted to experimental data obtained from published literature. The advantage of our model is that it includes relationships between the reaction rate, the concentrations of three substrates (GTP, IMP and ASP), the effects of five inhibitors (GMP, GDP, AMP, ASUC and SUCC), and the influence of Mg2+ ions.

Conclusion

Our model describes the react

SUBMITTER: Oshchepkova-Nedosekina EA 

PROVIDER: S-EPMC1808444 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature