Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses.

ABSTRACT:

Background

Respiratory infection with the neurovirulent vaccinia virus (VV) strain Western Reserve (WR) results in an acute infection of the lung followed by dissemination of the virus to other organs and causes lethality in mice. The mechanisms of lethality are not well-understood. In this study, we analyzed virus replication and host immune responses after intranasal infection with lethal and non-lethal doses of VV using the WR strain and the less virulent Wyeth strain.

Results

The WR strain replicated more vigorously in the lung and in the brain than the Wyeth strain. There were, however, no differences between the virus titers in the brains of mice infected with the higher lethal dose and the lower non-lethal dose of WR strain, suggesting that the amount of virus replica

SUBMITTER: Hayasaka D 

PROVIDER: S-EPMC1810241 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature