Origins of amino acid transporter loci in trypanosomatid parasites.

ABSTRACT:

Background

Large amino acid transporter gene families were identified from the genome sequences of three parasitic protists, Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. These genes encode molecular sensors of the external host environment for trypanosomatid cells and are crucial to modulation of gene expression as the parasite passes through different life stages. This study provides a comprehensive phylogenetic account of the origins of these genes, redefining each locus according to a positional criterion, through the integration of phyletic identity with comparative gene order information.

Results

Each locus was individually specified by its surrounding gene order and associated with homologs showing the same position ('homoeologs') in other species, where

SUBMITTER: Jackson AP 

PROVIDER: S-EPMC1810246 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature