Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets.

ABSTRACT: The clinical phenotype of human dilated cardiomyopathy (DCM) encompasses a broad spectrum of etiologically distinct disorders. As targeting of etiology-related pathogenic pathways may be more efficient than current standard heart failure treatment, we obtained the genomic expression profile of a DCM subtype characterized by cardiac inflammation to identify possible new therapeutic targets in humans. In this inflammatory cardiomyopathy (DCMi), a distinctive cardiac expression pattern not described in any previous study of cardiac disorders was observed. Two significantly altered gene networks of particular interest and possible interdependence centered around the cysteine-rich angiogenic inducer 61 (CYR61) and adiponectin (APN) gene. CYR61 overexpression, as in human DCMi hearts in situ, wa

SUBMITTER: Wittchen F 

PROVIDER: S-EPMC1820750 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature