MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system.

ABSTRACT: MEGF9 [multiple EGF (epidermal growth factor)-like-domains 9], a novel transmembrane protein with multiple EGF-like repeats, is predominantly expressed in the developing and adult CNS (central nervous system) and PNS (peripheral nervous system). The domain structure of MEGF9 consists of an N-terminal region with several potential O-glycosylation sites followed by five EGF-like domains, which are highly homologous with the short arms of laminins. Following one single pass transmembrane domain, a highly conserved short intracellular domain with potential phosphorylation sites is present. The protein was recombinantly expressed and characterized as a tissue component. To study the expression pattern further, immunohistochemistry was performed and staining was detected in Purkinje cells of the

SUBMITTER: Brandt-Bohne U 

PROVIDER: S-EPMC1820795 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature