A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates.

ABSTRACT:

Background

Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen, causing more than 200 cases of severe human infection worldwide, with the hallmarks of meningitis, septicemia, arthritis, etc. Very recently, SS2 has been recognized as an etiological agent for streptococcal toxic shock syndrome (STSS), which was originally associated with Streptococcus pyogenes (GAS) in Streptococci. However, the molecular mechanisms underlying STSS are poorly understood.

Methods and findings

To elucidate the genetic determinants of STSS caused by SS2, whole genome sequencing of 3 different Chinese SS2 strains was undertaken. Comparative genomics accompanied by several lines of experiments, including experimental animal infection, PCR assay, and expression analysis, were utili

SUBMITTER: Chen C 

PROVIDER: S-EPMC1820848 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature