Gene-expression variation within and among human populations.

ABSTRACT: Understanding patterns of gene-expression variation within and among human populations will provide important insights into the molecular basis of phenotypic diversity and the interpretation of patterns of expression variation in disease. However, little is known about how gene-expression variation is apportioned within and among human populations. Here, we characterize patterns of natural gene-expression variation in 16 individuals of European and African ancestry. We find extensive variation in gene-expression levels and estimate that approximately 83% of genes are differentially expressed among individuals and that approximately 17% of genes are differentially expressed among populations. By decomposing total gene-expression variation into within- versus among-population components, we

SUBMITTER: Storey JD 

PROVIDER: S-EPMC1821107 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature